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Landscape of cohesin-mediated chromatin loops in the human genome
Cell lines The cell types and lines in this study were either obtained from cell repositories or established or differentiated in the Snyder and Dalton laboratories at Stanford University and the University of Georgia, respectively (Supplementary Tables 1, 2). All tissue culture was done according to the manufacturer’s recommendations. One of the commercially available cell lines, K1 (thyroid, papillary carcinoma), is on the list of commonly misidentified cell lines (ICLAC). The relevant cell line (CVCL_9918) was also derived from a thyroid papillary carcinoma. In the event of misidentification, the conclusions of our study would not be affected because both cell lines represent papillary thyroid carcinoma. ChIA-PET experiments We performed ChIA-PET…