What are the climate costs of plastic?

This article is the first of a two-part series on plastic and climate change. The second article will be published on 14 March 2022.

Found from the peaks of Mount Everest to the depths of the ocean and inside every organ in our body, plastic is all around us, in us and will outlive us.

Ubiquitous, versatile and disposable, plastic has shaped the modern age in a way that few other materials have. Plastic is used in virtually every industry in a staggering range of forms: packaging, clothes, electronic components, consumer products and construction, to name only a very few. 

Nowadays it is also infamous for its tendency to clog waterways and beaches, get eaten by turtles or accumulate in gigantic landfills. And, it’s developing a reputation as a driver of global warming. A study published last year in Nature Sustainability calculated the carbon footprint of the plastic industry to be 2 gigatonnes of greenhouse gas emissions, or 4.5 percent of the world’s total emissions, in 2015.

But how exactly does humanity’s addiction to plastic contribute to climate change? In this article, we’ll look at the ways we produce and dispose of plastic and how these lead to emissions. Then, in the next article in this series, we’ll dive into the climate change impact of plastic that ends up in our oceans as well as what we can do next.

Nurdles, which are pre-production plastic material that is shipped to manufacturers to be molded into products. Mark Dixon, Flickr
Nurdles, which are pre-production plastic material that is shipped to manufacturers to be molded into products. Mark Dixon, Flickr

The birth of plastic

Broadly speaking, plastics are materials composed of man-made “polymers” – large molecules built from repeating chains of small molecules called “monomers.” 

Humans have used naturally moldable materials for thousands of years. The use of rubber, for example, dates back to the ancient Olmec civilization. But new substances started to be developed during the 19th century, and the following century saw an explosion of plastic development and mass production. Given its low production cost and many useful applications, plastic has boomed over recent decades. In 2020, the world created an estimated 367 million tonnes of plastic.

It is, however, likely to leave an increasingly large climate footprint, according to a 2019 report by the Center for International Environmental Law (CIEL), which estimates that plastic production could in total emit 56 gigatonnes of greenhouse gas emissions by 2050. This equates to more than 10 percent of the entire remaining carbon budget set out by Intergovernmental Panel on Climate Change (IPCC) to try and limit warming to 1.5 degrees Celsius since the Industrial Revolution.

Every step of the plastic production chain emits greenhouse gases. Nearly all plastic resins are derived from fossil fuels – mainly natural gas and oil, but also some from coal. Other than the emissions generated from using these fossil fuels as the feedstock for plastic, extracting fossil fuels can also lead to greenhouse gas emissions in various other ways, including through flaring, methane leakages, and the energy used to drill and extract oil or gas. Carbon is also released when forests and vegetation is cleared to construct pipelines and wellpads.

After oil and gas is extracted, they are sent to “cracking” plants, where they are broken down into monomers before being stitched together in long chains to create polymers, the building blocks of plastic. Afterwards, plasticizers or other chemicals may be added to the plastic before it is cooled and shredded into tiny pellets called nurdles, which are then shipped to manufacturers to be formed into bags, textiles and other goods. 

This process emits an intense amount of greenhouse gases. Just within the U.S., plastic manufacturing is thought to add 114 million U.S. tons (103.4 million tonnes) of carbon dioxide equivalent every year, according to a report released last year by Beyond Plastics, a U.S.-based group that aims to end plastic pollution. The report states that this number is expected to grow, with at least 42 more plastics facilities coming under operation, construction or the permitting process in the country since 2019.

Judith Enck, the president of Beyond Plastics, says that most cracker facilities within the U.S. are proposed in low-income areas, especially around communities of color. “It’s as if we’ve created ‘sacrifice zones,’ where there are entire neighborhoods that are battered with air pollution and water pollution that’s making a lot of people sick,” she says.

“I think it’s really troubling that the phrase ‘Cancer Alley’ [the 85-mile stretch of land containing 25 percent of the U.S.’s petrochemical production] just flows off our tongues. But that’s what that stretch of the Mississippi River is called. Cancer Alley.”

Coal is a growing source of plastic production-derived carbon emissions, according to recent research. Darmau Lee, Unsplash
Coal is a growing source of plastic production-derived carbon emissions, according to recent research. Darmau Lee, Unsplash

Natural gas is the main plastic feedstock used in the U.S., due to an abundant supply as a result of the shale gas boom of recent years. But oil is a major feedstock in the rest of the world. The World Economic Forum estimates that roughly 4 to 8 percent of oil extracted globally is then used for plastic, half of which is used as material feedstock and the other half used to provide energy for the production process, leading to the CIEL report authors to roughly estimate that, outside the U.S., producing plastic from oil releases 108 million tonnes of carbon dioxide equivalent every year. 

However, the role of coal in plastic production is rapidly growing – especially as global plastic production is increasingly reliant on coal-dependent countries like China, Indonesia and South Africa. The aforementioned study published in Nature Sustainability found that this trend has doubled the carbon and health footprint (as relates to particulate matter) of plastic production since 1995.

“One factor might be that in wealthy countries we have more strict environmental guidelines, and this can even lead to this shift – we also call it ‘outsourcing’ – of the dirty steps like plastic production to other countries where we don’t have these strict guidelines,” says Livia Cabernard, a post-doctoral researcher at ETH Zürich and one of the authors of the study. She added that a consumer preference for cheaper products and increasing Western imports of commodities like electronics and machinery might also explain this trend.

The research found coal to be the source of 44 percent of plastic production emissions, mainly for electricity generation and for resin production and manufacturing. Even though 88 percent of the carbon emissions and 93 percent of the health impacts from plastic production occurred in countries outside Europe and the U.S., Western countries enjoyed 80 percent of the economic value of these plastics.

Cabernard added that outsourcing plastic production to these coal-dependent countries meant that it is harder for them to achieve their climate commitments to reduce greenhouse gas emissions, because “what counts in these climate agreements are our domestic emissions, which indeed in many high-income regions have decreased. But on the other hand, when we look at our consumption-based impacts, they actually have increased…we just cause the impacts somewhere else.”

A landfill in Arizona, U.S. Alan Levine, Flickr
A landfill in Arizona, U.S. Alan Levine, Flickr

The difficult disposal of plastic

The wonderful qualities of plastic when in use are also its environmental downfall. Its resistance to water and durability means that it degrades very slowly, and depending on the type of plastic and environment, it can take decades or even centuries to break down. In fact, the bulk of most plastic’s existence happens after it is disposed , typically after being used only once. It is after we throw plastic away that its life begins to diverge into a variety of paths – and emit carbon in various ways.

Plastic is usually landfilled, incinerated or recycled. Ideally, all plastic would be recycled in perpetuity, but in reality, only about 9 percent of all plastic ever produced has been recycled just once. The costs of recycling compared with the cheapness of making new plastic results in much of the world’s used plastic, even when cleaned and thrown into the recycling bin, being landfilled or incinerated. Infinite reuse is also impossible, because plastic’s quality degrades each time it is repurposed.

So around 60 percent of all plastic made since 1950 has been either sent to landfills – where it emits methane and carbon dioxide and can lead to soil, groundwater and smell pollution for nearby communities – or discarded in the natural environment.

The most emissions-heavy way to manage plastic waste is to burn it. From 1950 to 2015, around 12 percent of all discarded plastic was incinerated. Facilities that incinerate waste (which usually includes both plastic and other disposed material) for energy can now be found around the world. The logic is to take various types of waste material and burn it into fuels to be reused as power. Many municipalities have adopted this technology in order to reduce the waste that ends up in landfills while displacing some fossil fuel dependency. 

But according to the CIEL report, for every tonne of plastic burned, 0.9 tonnes of carbon dioxide equivalent are still released, even after accounting for the fossil fuel use it displaces. This means that plastic incineration, including when it is burned for energy use, emits far more greenhouse gas emissions than both landfilling or recycling.

And the fossil fuel “offset” will become less valid as economies decarbonize and switch to using renewable energy. According to Janek Vähk, the Climate, Energy, Air Pollution programme coordinator at Zero Waste Europe, waste incineration could come to occupy 7 percent of the total European carbon budget in a future that keeps global warming to 1.5 degrees Celsius. 

“A lot of waste which is currently incinerated actually is recyclable, but it ends up incinerated because it’s the simplest thing to do,” Vähk says. “It’s just something to do with economics: waste incineration is cheaper than recycling. Why bother with all the separate collection, recycling and so on if you could just simply burn it and get a little bit of energy out of it?”

The emissions from incineration waste for energy can vary, depending on the type of energy used to power the incinerator and the type of waste burned. It is often not simply pure plastic that is incinerated but mixed municipal waste, which could require more energy for the incineration process. For example, more energy is needed to burn plastic mixed with food or other organic material that could contain more moisture, which then reduces the fossil fuel offset. The U.S. Environmental Protection Agency estimated that the emissions from waste-to-energy incineration in 2016 from the U.S. alone was 11 million tonnes of carbon dioxide equivalent.

According to a recent report by Zero Waste Europe, these incineration facilities can contaminate surrounding communities with persistent organic pollutants, also known as “forever chemicals,” as was found with the waste incinerators the authors studied in Spain, the Czech Republic and Lithuania. These pollutants gradually accumulate within living things in the environment and can harm human health over time. For example, they found that most of the chicken eggs from communities surrounding the incineration facilities had higher levels of toxins than permitted for sale or consumption. 

Plastic waste, recyclable or not, is often traded globally on cargo ships. Rinson Chory, Unsplash
Plastic waste, recyclable or not, is often traded globally on cargo ships. Rinson Chory, Unsplash

Yet the plastic waste generated in many countries is often overwhelming, to the point that many export it to be managed elsewhere. The primary destination was once China, until it banned most plastic waste imports in 2018. This resulted in the trade being diverted to other Asian countries – either legally or illegally – including Malaysia, which was the top importer of plastic waste in 2020. A report by the Environmental Investigation Agency last year found that despite only having a recycling capacity of 515,009 tonnes, Malaysia imports roughly 835,000 tonnes of foreign plastic waste each year – even while producing 2.4 million tonnes domestically. 

Mageswari Sangaralingam, a senior research officer with Friends of the Earth Malaysia, said that after China banned plastic imports, communities near Port Klang (a major port in Malaysia) began to experience breathing difficulties. After investigating on their own, they detected some illegal recycling plants near their agricultural areas.

“[The recycling plants] were just dumping it. And sometimes [plastic dumps] catch fire, so it’s in flames. Or sometimes they intentionally burn it,” says Sangaralingam. She said that Friends of the Earth Malaysia and other groups then assisted the communities in appealing to the authorities to address the problem by reaching out to international media to bring attention to this issue. “Thailand, Vietnam and Indonesia, they all became a dumping ground for this waste from developed countries.”

Batches of plastic waste that contain a mix of resins or that are contaminated with non-plastic material are often difficult to recycle and are thus often illegal to import, but shipping containers holding imported waste might be mislabeled to obscure this. The Basel Convention, an international treaty that aims to reduce the trade in hazardous waste, was amended in 2019 to also include plastic.

Nevertheless, the waste trade continues. Since many countries lack the capacity to manage such large quantities of plastic waste or because the plastic is unrecyclable, it is often dumped, openly burned or lost into the environment, at which point its climate impact becomes more difficult to measure. Every year, between 5 and 12 million tonnes of plastic waste are thought to be leaked into waterways before ultimately ending up in the ocean.

Read on in part 2 of this series on plastics.

Modeling how antibody responses may determine the efficacy of COVID-19 vaccines

  • Wouters, O. J. et al. Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation and deployment. Lancet 397, 1023–1034 (2021).


    Google Scholar
     

  • Forni, G. & Mantovani, A. COVID-19 vaccines: where we stand and challenges ahead. Cell Death Differ. 28, 626–639 (2021).


    Google Scholar
     

  • Shrotri, M., Swinnen, T., Kampmann, B. & Parker, E. P. K. An interactive website tracking COVID-19 vaccine development. Lancet Glob. Health 9, e590–e592 (2021).


    Google Scholar
     

  • Koup, R. A. et al. A government-led effort to identify correlates of protection for COVID-19 vaccines. Nat. Med. 27, 1493–1494 (2021).


    Google Scholar
     

  • Saad-Roy, C. M. et al. Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes. Science 372, 363–370 (2021).


    Google Scholar
     

  • Bubar, K. M. et al. Model-informed COVID-19 vaccine prioritization strategies by age and serostatus. Science 371, 916–921 (2021).


    Google Scholar
     

  • Voysey, M. et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet 397, 881–891 (2021).


    Google Scholar
     

  • Garg, A. K., Mittal, S., Padmanabhan, P., Desikan, R. & Dixit, N. M. Increased B cell selection stringency in germinal centers can explain improved COVID-19 vaccine efficacies with low dose prime or delayed boost. Front. Immunol. 12, 776933 (2021).


    Google Scholar
     

  • Tauzin, A. et al. Strong humoral immune responses against SARS-CoV-2 spike after BNT162b2 mRNA vaccination with a 16-week interval between doses. Cell Host Microbe 30, 97–109 (2022).


    Google Scholar
     

  • Baden, L. R. et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N. Engl. J. Med. 384, 403–416 (2021).


    Google Scholar
     

  • Polack, F. P. et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 Vaccine. N. Engl. J. Med. 383, 2603–2615 (2020).


    Google Scholar
     

  • Logunov, D. Y. et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet 397, 671–681 (2021).


    Google Scholar
     

  • Ella, R. et al. Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial. Lancet 398, 2173–2184 (2021).


    Google Scholar
     

  • Jara, A. et al. Effectiveness of an inactivated SARS-CoV-2 vaccine in Chile. N. Engl. J. Med. 385, 875–884 (2021).


    Google Scholar
     

  • Sadoff, J. et al. Safety and efficacy of single-dose Ad26.COV2.S vaccine against COVID-19. N. Engl. J. Med. 384, 2187–2201 (2021).


    Google Scholar
     

  • Heath, P. T. et al. Safety and efficacy of NVX-CoV2373 COVID-19 vaccine. N. Engl. J. Med. 385, 1172–1183 (2021).


    Google Scholar
     

  • Khoury, D. S. et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat. Med. 27, 1205–1211 (2021).


    Google Scholar
     

  • Earle, K. A. et al. Evidence for antibody as a protective correlate for COVID-19 vaccines. Vaccine 39, 4423–4428 (2021).


    Google Scholar
     

  • Feng, S. et al. Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection. Nat. Med. 27, 2032–2040 (2021).


    Google Scholar
     

  • Barrett, J. R. et al. Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses. Nat. Med. 27, 279–288 (2021).


    Google Scholar
     

  • Israelow, B. et al. Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2. Sci. Immunol. 6, eabl4509 (2021).


    Google Scholar
     

  • Gilbert, P. B. et al. Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial. Science 375, 43–50 (2022).


    Google Scholar
     

  • Addetia, A. et al. Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with a high attack rate. J. Clin. Microbiol. 58, e02107–e02120 (2020).


    Google Scholar
     

  • Lumley, S. F. et al. Antibody status and incidence of SARS-CoV-2 infection in health care workers. N. Engl. J. Med. 384, 533–540 (2020).


    Google Scholar
     

  • Callow, K. A. Effect of specific humoral immunity and some non-specific factors on resistance of volunteers to respiratory coronavirus infection. J. Hyg. 95, 173–189 (1985).


    Google Scholar
     

  • Liu, L. et al. Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature 584, 450–456 (2020).


    Google Scholar
     

  • Robbiani, D. F. et al. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature 584, 437–442 (2020).


    Google Scholar
     

  • Folegatti, P. M. et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet 396, 467–478 (2020).


    Google Scholar
     

  • Perelson, A. S. & Oster, G. F. Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. J. Theor. Biol. 81, 645–670 (1979).

    MathSciNet 

    Google Scholar
     

  • Chi, X. et al. A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science 369, 650–655 (2020).


    Google Scholar
     

  • Wang, C. et al. A human monoclonal antibody blocking SARS-CoV-2 infection. Nat. Commun. 11, 2251 (2020).


    Google Scholar
     

  • Seydoux, E. et al. Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation. Immunity 53, 98–105 e105 (2020).


    Google Scholar
     

  • Shi, R. et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature 584, 120–124 (2020).


    Google Scholar
     

  • Wec, A. Z. et al. Broad neutralization of SARS-related viruses by human monoclonal antibodies. Science 369, 731–736 (2020).


    Google Scholar
     

  • Lei, C. et al. Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig. Nat. Commun. 11, 2070 (2020).


    Google Scholar
     

  • Lv, Z. et al. Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science 369, 1505–1509 (2020).


    Google Scholar
     

  • Zost, S. J. et al. Potently neutralizing and protective human antibodies against SARS-CoV-2. Nature 584, 443–449 (2020).


    Google Scholar
     

  • Ju, B. et al. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 584, 115–119 (2020).


    Google Scholar
     

  • Cao, Y. et al. Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients’ B cells. Cell 182, 73–84 (2020).


    Google Scholar
     

  • Hansen, J. et al. Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail. Science 369, 1010–1014 (2020).


    Google Scholar
     

  • Rogers, T. F. et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science 369, 956–963 (2020).


    Google Scholar
     

  • Barnes, C. O. et al. Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies. Cell 182, 828–842 (2020).


    Google Scholar
     

  • Pinto, D. et al. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature 583, 290–295 (2020).


    Google Scholar
     

  • Hanke, L. et al. An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Nat. Commun. 11, 4420 (2020).


    Google Scholar
     

  • Webb, N. E., Montefiori, D. C. & Lee, B. Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies. Nat. Commun. 6, 8443 (2015).


    Google Scholar
     

  • Padmanabhan, P. & Dixit, N. M. Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations. Proc. Natl Acad. Sci. USA 114, E4524–E4526 (2017).


    Google Scholar
     

  • Jilek, B. L. et al. A quantitative basis for antiretroviral therapy for HIV-1 infection. Nat. Med. 18, 446–451 (2012).


    Google Scholar
     

  • Isho, B. et al. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci. Immunol. 5, eabe5511 (2020).


    Google Scholar
     

  • Iyer, A. S. et al. Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Sci. Immunol. 5, eabe0367 (2020).


    Google Scholar
     

  • Röltgen, K. et al. Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome. Sci. Immunol. 5, eabe0240 (2020).


    Google Scholar
     

  • Shrock, E. et al. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science 370, eabd4250 (2020).


    Google Scholar
     

  • Yuan, M. et al. Structural basis of a shared antibody response to SARS-CoV-2. Science 369, 1119–1123 (2020).


    Google Scholar
     

  • Meyer, C. T. et al. Quantifying drug combination synergy along potency and efficacy axes. Cell Syst. 8, 97–108 (2019).


    Google Scholar
     

  • Widge, A. T. et al. Durability of responses after SARS-CoV-2 mRNA-1273 vaccination. N. Engl. J. Med. 384, 80–82 (2021).


    Google Scholar
     

  • McMahan, K. et al. Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature 590, 630–634 (2021).


    Google Scholar
     

  • Sette, A. & Crotty, S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell 184, 861–880 (2021).


    Google Scholar
     

  • Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Nature 581, 465–469 (2020).


    Google Scholar
     

  • Neant, N. et al. Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort. Proc. Natl Acad. Sci. USA 118, e2017962118 (2021).


    Google Scholar
     

  • Kissler, S. M. et al. Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies. PLoS Biol. 19, e3001333 (2021).


    Google Scholar
     

  • Desikan, R., Raja, R. & Dixit, N. M. Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection. PLoS Comput. Biol. 16, e1008064 (2020).


    Google Scholar
     

  • Yu, J. et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science 369, 806–811 (2020).


    Google Scholar
     

  • Yang, S., Jerome, K. R., Greninger, A. L., Schiffer, J. T. & Goyal, A. Endogenously produced SARS-CoV-2 specific IgG antibodies may have a limited impact on clearing nasal shedding of virus during primary infection in humans. Viruses 13, 516 (2021).


    Google Scholar
     

  • van Gils, M. J. & Sanders, R. W. In vivo protection by broadly neutralizing HIV antibodies. Trends Microbiol. 22, 550–551 (2014).


    Google Scholar
     

  • Fajnzylber, J. et al. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nat. Commun. 11, 5493 (2020).


    Google Scholar
     

  • Arnaout, R. et al. SARS-CoV2 testing: the limit of detection matters. Preprint at bioRxiv https://doi.org/10.1101/2020.06.02.131144 (2020).

  • Gonçalves, A. et al. Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load. CPT Pharmacometrics Syst. Pharm. 9, 509–514 (2020).


    Google Scholar
     

  • Goyal, A., Cardozo-Ojeda, E. F. & Schiffer, J. T. Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response. Sci. Adv. 6, eabc7112 (2020).


    Google Scholar
     

  • Dagan, N. et al. BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting. N. Engl. J. Med. 384, 1412–1423 (2021).


    Google Scholar
     

  • Walsh, E. E. et al. Safety and immunogenicity of two RNA-based COVID-19 vaccine candidates. N. Engl. J. Med. 383, 2439–2450 (2020).


    Google Scholar
     

  • Anderson, E. J. et al. Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adult. N. Engl. J. Med. 383, 2427–2438 (2020).


    Google Scholar
     

  • Maisonnasse, P. et al. COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models. Nat. Commun. 12, 6097 (2021).


    Google Scholar
     

  • Chigutsa, E., O’Brien, L., Ferguson-Sells, L., Long, A. & Chien, J. Population pharmacokinetics and pharmacodynamics of the neutralizing antibodies bamlanivimab and etesevimab in patients with mild to moderate COVID-19 infection. Clin. Pharmacol. Ther. 110, 1302–1310 (2021).


    Google Scholar
     

  • Saha, A. & Dixit, N. M. Pre-existing resistance in the latent reservoir can compromise VRC01 therapy during chronic HIV-1 infection. PLoS Comput. Biol. 16, e1008434 (2020).


    Google Scholar
     

  • Krammer, F. A correlate of protection for SARS-CoV-2 vaccines is urgently needed. Nat. Med. 27, 1147–1148 (2021).


    Google Scholar
     

  • Chatterjee, B., Sandhu, H. S. & Dixit, N. M. The relative strength and timing of innate immune and CD8 T-cell responses underlie the heterogeneous outcomes of SARS-CoV-2 infection. Preprint at medRxiv https://doi.org/10.1101/2021.06.15.21258935 (2021).

  • Padmanabhan, P., Garaigorta, U. & Dixit, N. M. Emergent properties of the interferon-signalling network may underlie the success of hepatitis C treatment. Nat. Commun. 5, 3872 (2014).


    Google Scholar
     

  • Perelson, A. S. & Ke, R. Mechanistic modeling of SARS-CoV-2 and other infectious diseases and the effects of therapeutics. Clin. Pharmacol. Ther. 109, 829–840 (2020).


    Google Scholar
     

  • Baum, A. et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science 369, 1014–1018 (2020).


    Google Scholar
     

  • Padmanabhan, P. & Dixit, N. M. Modeling suggests a mechanism of synergy between hepatitis C virus entry inhibitors and drugs of other classes. CPT Pharmacometrics Syst. Pharm. 4, 445–453 (2015).


    Google Scholar
     

  • Chou, T. C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharm. Rev. 58, 621–681 (2006).


    Google Scholar
     

  • Padmanabhan, P., Desikan, R. & Dixit, N. M. Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection. PLoS Comput. Biol. 16, e1008461 (2020).


    Google Scholar
     

  • Brouwer, P. J. M. et al. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability. Science 369, 643–650 (2020).


    Google Scholar
     

  • Kim, K. S. et al. A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2. PLoS Biol. 19, e3001128 (2021).


    Google Scholar
     

  • Zarnitsyna, V. I. et al. Mathematical model reveals the role of memory CD8 T cell populations in recall responses to influenza. Front. Immunol. 7, 165 (2016).


    Google Scholar
     

  • Benotmane, I. et al. Biomarkers of cytokine release syndrome predict disease severity and mortality from COVID-19 in kidney transplant recipients. Transplantation 105, 158–169 (2021).


    Google Scholar
     

  • Ke, R. et al. Daily sampling of early SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness. Preprint at medRxiv https://doi.org/10.1101/2021.07.12.21260208 (2021).

  • Golob, J. L., Lugogo, N., Lauring, A. S. & Lok, A. S. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight 6, e149187 (2021).


    Google Scholar
     

  • Zhang, Y. et al. Safety, tolerability and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. Lancet Infect. Dis. 21, 181–192 (2021).


    Google Scholar
     

  • Jackson, L. A. et al. An mRNA vaccine against SARS-CoV-2—preliminary report. N. Engl. J. Med. 383, 1920–1931 (2020).


    Google Scholar
     

  • Padmanabhan, P., Desikan, R. & Dixit, N. M. COVID-19 vaccine efficacies. Zenodo https://doi.org/10.5281/zenodo.5879304 (2022).

  • Landscape conservation strategy: A pathway to Vision 2030

    The Herald

    The growth of a Center Zambezi Landscape Conservation System provides an revolutionary and proactive method to conserve and utilise purely natural methods for social and financial growth in the northern most position of Zimbabwe straddling the Zambian border. In this report, Agric, Environment & Innovations Editor, Sifelani Tsiko (ST), speaks to African Wildlife Foundation Zimbabwe state director Olivia Mufute (OM) on why valuing natural money can help the Governing administration to account for nature’s job in the financial system and in the attainment of the Eyesight 2030 ambitions.

    ST: Why the Middle Zambezi Landscape Conservation System?

    OM: We are bringing technological specialists and other stakeholders to craft the method to make a statement all around a daring eyesight for the future of our place. 

    We’re connecting the land, waters of the Zambezi to assist balanced ecosystems, thriving fish and wildlife populations and vivid communities. 

    Zimbabwe has a shared responsibility to conserving its pure heritage and passing it on to long run generations.

    ST: What is the key reason for creating the Center Zambezi Landscape Conservation Method?

    OM: The most important rationale for this is to guarantee that the Mid-Zambezi Landscape is conserved when at the exact same time contributing to Zimbabwe’s economic advancement. This landscape is incredibly beneficial mainly because of its rich biodiversity. 

    It is of enormous ecological significance not only to Zimbabwe, but to the location as a complete. It is amid Zimbabwe’s 4 vital elephant ranges.

    ST: What are the important components of this tactic?

    OM: We are aligning this method with the AWF’s interior framework – the Landscape Conservation Procedure (LCP), a participatory, proof-primarily based framework utilized to strategy, employ and measure conservation impression. 

    We also want it to be in line with the Countrywide Advancement Technique (NDS1) for the following 10 many years for the Mid-Zambezi Landscape.

    ST: Does this approach assistance the country’s NDS1 and Vision 2030 aims?

    OM: Certainly, it does. The Center Zambezi Landscape Conservation Method is in fact knowledgeable by the NDS1. The AWF actively participated in the complex doing work team on ecosystem throughout the improvement of NDS1. 

    So, it is there to assistance NDS1 and it is also linked to the new AWF Zimbabwe Place Conservation System 2020-2030. It mainly aims to assistance the state achieve its vision of becoming a center money financial state by 2030. 

    By developing this method, we want to make absolutely sure that we actualise the implementation of the national vision and troubles articulated in NDS1.

    ST: What is the significance of national accounting of the surroundings to this strategy?

    OM: Presently, Zimbabwe has initiated – through the ministries of finance and environment – a study to quantify the contribution of our biodiversity to the countrywide economic system. This landscape system will lead to a much better comprehension of the standing and worth of the biodiversity in the Mid-Zambezi. 

    There is a approach which is underway to acquire a framework for countrywide cash accounting. It would be pretty important to keep an eye on the contribution and progress of this sector heading forwards.

    ST: When do you think the crafting of the tactic would be completed?

    OM: It is not a extended system and we hope to maintain consultative processes with thematic teams and authorities within just a really short time. It should take us it’s possible 3 months.

    ST: How will this strategy be valuable to the neighborhood group?

    OM: This technique will be advantageous to the nearby communities for the reason that ideal now, they are portion and parcel of the consultative process. They are environment the targets for the concerns that they want prioritised on the ground by themselves. 

    In the circumstance of Mbire District Council where there is a land use approach, community communities are guaranteeing that the system is in line with the problems currently determined – connectivity, conservation targets, feasible wildlife populations, small business prospects, habitat connectivity and so on.

    ST: What kind of assist is the AWF heading to be offering in the implementation of this tactic?

    OM: The AWF has invested extensively in acquiring this tactic by utilizing its individual interior sources. The level of representation is quite massive at this conference – we have a few vice presidents of the AWF which include complex specialists from Washington DC, South Africa, Cameroon and Kenya. 

    This demonstrates our complete commitment to the Mid-Zambezi Landscape Conservation Tactic. It also demonstrates our lengthy-time period motivation to get the job done in this landscape.

    AWF has also invited a variety of community stakeholders, like donors, improvement companions, community companies and the Government. 

    AWF also sees a lot of chances for partnership with the personal sector to assure lengthy expression funding together with donor and bilateral funding. 

    It has discovered Zimbabwe as a focal place amid 5 priority nations in Africa. We are heading to invest extensively in Zimbabwe about the next 10 yrs or much more.

    ST: Looking ahead, what are your hopes for the Mid-Zambezi Landscape Conservation System?

    OM: We are hoping to carry out suggestions from this system. We are also on the lookout ahead to boosting suitable money and other methods and to produce partnerships with nearby and intercontinental buyers to increase nearby neighborhood livelihoods. 

    We want to bring in lengthy-time period expense that is inexperienced and climate smart. 

    We want this method to add meaningfully to the developing of resilient regional communities with different livelihood selections. We envisage wholesome and functioning ecosystems, flourishing fish and wildlife populations and vivid communities.

    Temporary pause on large-scale solar makes sense

    Revealed: 2/22/2022 2:02:48 PM

    Modified: 2/22/2022 2:02:25 PM

    When the Amherst City Council convenes on Feb. 28, the fate of a short term moratorium on big-scale photo voltaic will be resolved. The moratorium will suspend the progress of any floor-mounted photo voltaic bigger than 250 kilowatt for the following 14 months, unless a photo voltaic bylaw, governing massive scale solar improvement, is designed before then.

    Amherst should really be commended for going ahead diligently. Together with the site and probable dimension of new arrays, we are entering a new era in Amherst for industrialized solar. Amherst’s earlier photo voltaic projects had been mostly sited on open up land, neither forest nor farmland. The disorders bordering the advancement of solar arrays like the a person close to Cherry Hill and the just one across from Atkins Sector were being solely different. Neither one particular expected distinct reducing 45 acres of forest land.

    Exactly where solar really should be, in Amherst and the area, is the significant problem. How much ought to the town’s Learn System, which phone calls for maintaining vital tracts of the optimum good quality habitats undeveloped and permanently guarded, tutorial our choices? Furthermore, the Learn Strategy calls for the identification and long lasting protection of lands buffering Amherst drinking water source, wells and reservoirs from growth. Can it be finished?

    For Amherst, a photo voltaic siting assessment operating group is currently being produced to wrestle with these central inquiries. The doing the job team will be billed, in portion, with examining the impacts of substantial-scale photo voltaic enhancement, together with battery storage, on our community and non-public h2o supplies on wildlife on erosion on hearth and hazardous material run off problems.

    The siting examine will discover possibilities for solar all through the neighborhood: in the developed surroundings — on roof tops, parking lot canopies and in the all-natural landscape. With any luck ,, it will compute the duty that the faculties and college need to bear in carrying out their component. This will be an outstanding group to direct the way to liable progress of photo voltaic energy. Why would we want to let assignments to shift ahead until eventually we complete this examine?

    By using the time that a moratorium offers, we can find out a great deal from other cities. The consequences of unsuccessful setting up and judgment can be critically essential classes uncovered. We have styles of what not to do. The ecological and environmental repercussions of misplaced solar can be disastrous. Just glimpse at what happened in Williamsburg and in Conway to see the effects of failed scheduling, which brought on irreparable destruction to bordering neighbors and neighborhoods in these cities.

    What do we achieve by having the time that a short term moratorium presents, time taken by cities like East Longmeadow, Charlton, Blanford, Granby, Athol, Wendell and other individuals?

    The present of time that we grant ourselves presents us the prospect to measure challenges and added benefits absolutely comprehend differing scientific views on siting solar understand the recommendations of Amherst’s Learn Strategy and at the same time interact the town to completely comprehend what it values when siting huge arrays. We have a excellent opportunity in advance to gain from other towns’ heritage with massive-scale photo voltaic from the skills the operating group will carry to the method and from the voices of the local community.

    As has been explained by many others at several general public meetings, why would not we have a short-term moratorium to just take this reasonably quick pause to get this proper? We have so a lot to attain!

    Eric Bachrach life in Amherst.

    Lee Schofield on how farming needs to re-wiggle its approach to nature

    “I smell snow,” Lee Schofield says as we leave the car and step into the UK Lake District’s magnificent and numbingly cold Swindale Valley. When I point out that he’s quoting a famous line from the Gilmore Girls, a TV show set in fictional small town America, he smiles with (understandable) bewilderment at the reference. He is not a natural people-person he later confesses, being drawn to the region for its quiet expanses. Yet much like the landscape itself, this self-effacing, reflective ecologist also finds himself in a position where responding to human narratives and emotion has become a defining part of his world.

    At RSPB Haweswater, Schofield is site-manager of two upland farms that the NGO is restoring to ecological health while continuing to operate as a viable agricultural business. As such he is attempting to bridge one of Britain’s most tense and wide-reaching rural divides. On the one side sits farming interests eager to protect their heritage and precarious livelihoods; on the other is the modern conservation movement, racing to pull nature back from the brink. Similar to many civil or internecine conflicts, it is all the more intense for the parties’ closely linked passions. And mediation efforts can often feel similarly bleak.

    The cause of tension in this case is the RSPB’s attempt to rebalance hill farming and ecology. Renting their land from United Utilities, a water supply company, Schofield’s small team have “re-wiggled” rivers to help with flood prevention, repaired damaged wetlands, and experimented with new breeds of livestock. As well as continuing to farm the region’s sheep, albeit at reduced numbers, they have introduced Belted Galloway cows which are native to the UK and graze in a way that makes it possible for a wider range of plant species to also thrive (cattle being less selective than sheep in their munching).

    Local insects and wildlife have flourished as a result, along with improvements in water quality and carbon storage – all while maintaining the unique and Unesco-protected cultural heritage of the region. As Schofield jokes: “who doesn’t love a cow that looks like a Licorice Allsort?”

    The ultimate hope is to breathe enough life into the area that it can once again sustain golden eagles, the last of whom vanished from the UK in 2015 after spending more than a decade living alone in the nearby Eagle Crag. The eagles’ loss was a “potent symbol of wildness bleeding out of the landscape,” Lee writes in his book Wild Fell, and is still a source of both national and personal shame, having occurred on his watch.

    The RSPB’s mission is therefore timely: more than 70 per cent of the UK is used for agriculture and much of Britain’s biodiversity is on life support. But pursuing such a nature-focused farming project is not always easy. In some instances opposition is direct, Schofield writes: shepherds demanding excessive pay, open-day visitors dismissing staff as “idiots”, or the Unesco group committee describing the initiative as a “wart” on the face of the then-potential World Heritage Site. Other criticisms are more insidious still, with rumours, misrepresentations and gossip slipping across the landscape as regularly as escaping ewes.

    One particularly disheartening encounter occurred with the former local MP Rory Stewart, said Schofield. While quick to praise the “fiercely intelligent” and “approachable” author and academic, Schofield writes that he was bruised by what he describes as the about-turn Stewart made in his response to the project; first praising it in a blog on his website, then later posting a more critical summary of his site-visit, Schofield writes.

    Content from our partners

    Small firms face tough times, but have reason to hope

    The government's focus on lifelong learning must go further

    An agenda to boost employment and protect the UK

    Stewart told the New Statesman that be believes that “the sheep farming traditions of the Lake District are important to our national identity, our cultural heritage and particularly to those rural communities. I would much rather see rewilding in lowland England where the biodiversity benefits are greater and the loss to cultural heritage and small farms less.”

    Farmers’ fear of reform is often rooted in the recent history of misguided government subsidies, Schofield notes sympathetically. The EU’s Common Agricultural Policy prioritised livestock headcounts and pushed farmers into using evermore intensive methods and precarious profits, so the prospect of further change is daunting, Schofield suggests. He urges greater understanding of the plight of small farmers, even as he makes the case for shifting the system to benefit nature too.

    “It feels like we’re approaching a huge tipping point,” he told me as we walked past the site of a tree where a goosander duck used to nest before it was found shot through the neck. “Sheep have done a lot of damage over the years, not through farmers’ fault, but through [government] demand. We need to find a way for farming to fit back into the land’s carrying capacity again. There are lots and lots of different solutions – it’s not one thing or the other.”

    The empathetic attitude contrasts with the toxic polarisation that social media often elicits. And it will hopefully help counter the farmer-bashing sparked by terms such as “sheep-wrecked”, which the journalist George Monbiot has used to describe Lake District farms. But such a calm, diplomatic approach has also not been easy for Schofield to reach. After being beaten down by criticism of the Haweswater project, he sought help through professional talking therapy, started to run long-distance, and drew strength from the ever-growing conservation network that stretches from the Woodland Trust supporters to officials from the Environment Agency. 

    Now that tenacity is paying off, with more new farmers entering the profession and existing ones opening themselves up to trying new methods. A former lawyer has recently been in touch with Schofield for advice about starting a nearby farm along nature-friendly lines, Schofield notes hopefully. And it is a shift the world urgently needs – for as the latest IPPC climate report reminds, agroecology can store 20-33 per cent more soil carbon than conventional agriculture, reduce wildfire risk, improve biodiversity, and boost productivity and profits.

    Like the rivers it has re-bent, the Haweswater project is re-wiggling farming into a more sustainable alignment with nature. And by similarly refusing to operate in siloed straight lines, Schofield’s own journey towards greater collaboration may have lessons to teach both of the UK’s rural tribes.

    Wild Fell: Fighting for nature on a Lake District hill farm by Lee Schofield is now published by Doubleday.


    Desert X AlUla 2022 Draws on the History and Culture of the Saudi Arabian Landscape

    Desert X AlUla 2022 Draws on the History and Culture of the Saudi Arabian Landscape